Dr Shaoqing Lai was born in 1964. He graduated from the Fourth Army Medical School in 1987, obtained a Master’s degree of Chinese Academy of Medical Sciences and Peking Union Medical College in 2001. He worked as a Professor and Master Tutor in the Department of Endoscopy of National Cancer Center/ National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
He has been engaging in endoscopic diagnosis and treatment of digestive tumours. He has participated in the on-site scientific research of “early diagnosis and early treatment of oesophagal cancer” for many years and researched the whole course of carcinogenesis of gastric cardiac cancer.
He has published thirty papers. He won the excellent paper award of Chinese Journal of Oncology, Chin J Oncol in 2005. He also won the outstanding academic paper award of the Fifth China Association for Science and Technology Journal in 2008.
Dr Lai’s research paper titled, “Carcinogenesis is consequence of failure of tissue development” is an interesting read. Lai has attempted to unravel the basic understanding of Cancer.
Cancers are defined by the National Cancer Institute (NCI) as a “collection of diseases in which abnormal cells can divide and spread to nearby tissue”. As this definition suggests, cancers can arise in many parts of the body and in some cases spread to other parts of the body through the blood and lymph systems.
The global cancer burden is estimated to have risen to 18.1 million new cases and 9.6 million deaths in 2018. One in 5 men and one in 6 women worldwide develop cancer during their lifetime, and one in 8 men and one in 11 women die from the disease.
Worldwide, the total number of people who are alive within 5 years of a cancer diagnosis, called the 5-year prevalence, is estimated to be 43.8 million.
The increasing cancer burden is due to a multitude of factors, which include population growth and ageing. The changing prevalence of certain causes of cancer is linked to social and economic development. This is especially true in rapidly growing economies, where a shift is observed from cancers related to poverty and infections to cancers associated with lifestyles more typical of industrialized countries.
Dr Lai suggests the exploration of pathogenesis and therapy of cancer is primarily under the guidance of gene mutation theory. However, according to him the therapeutic effect of cancer is not up to the mark, and “many predictions of the gene mutation theory do not conform to actual phenomenon of cancer. “ He analysed that the research results of genetic molecular mutation do not help in simplification of the study. This analysis made him suspects the gene mutation theory and compels him to develop a better understanding of the nature of a tumour.
The research by Dr Lai explores the nature of cancer. He has done so in a theoretical method by the view of tissue regeneration.
Dr Lai concluded that tumours originated from tissue regeneration. Furthermore, the study examines how tumour cells originate from normal stem cells and how the factors contributed to tumorigenesis can be divided into tumour promoter and carcinogen. The theory also pointed out that gaining the capability of infiltration and metastasis does not need genetic mutation.
He also observed that tumour cells differentiated into normal mature inducers with appropriate inducers. In addition to this, it was noticed that normal stem cells would advance into tumour stem cells without suitable inducers.
When Dr Lai closely observed the results he found that the ultimate solution of a tumour is differentiation therapy and that stem cell transplantation should be cautiously approached.
This research has set a precedent and has opened further discussion on this fatal disease. A person suffering from cancer has exhaustion as well as a tumour. Dr Lai’s theory has faith in carcinogenesis being a consequence of the failure of tissue development. He also adds that the weak and feeble are more vulnerable to cancer. His study shows that a tumour may not be a cause of cancer. On the contrary, he suggests that it may be the consequence of the fatal disease. He has suggested that “the intestinal type gastric carcinogenesis may be a suitable model to test this hypothesis on solid tumour” and the same has been discussed in greater detail in his research.
Dr Lai has been able to gain first-hand knowledge because of his interaction with cancer patients every day, his rich clinical experience and his own understanding of cancer. All of this has immensely contributed in this exemplary achievement of his and will be held in high regard in cancer science.
Full Article Link: Carcinogenesis is consequence of failure of tissue development
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